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Given its numerous functions, low levels of thiamine can lead to reduced energy production due to impaired mitochondrial function, which damages neurons, and cells that have high energy demands, making them particularly vulnerable to potential damage or cell death (40)

Hypertension 68 (6), 14941503

More serious but less common adverse effects observed in trials or associated with this drug class include: Increased heart rate , a class effect seen with GLP-1 receptor agonists [15] [12] Gallbladder disease , including gallstones (cholelithiasis), which has been associated with rapid weight loss and incretin-based therapies more broadly

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation