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One step towards resolution would be to combine the cerebrospinal fluid specimens for standardized targeted mass spectrometry analysis followed by multivariate analysis of age, gender, exercise status and levels of severity such as poor quality of life, pain, fatigue and interoceptive complaints

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In a recent study in liver cirrhosis of any cause, not only urinary 51 Cr-EDTA excretion was elevated in about half the patients and associated with Child-Pugh state, it was also present in all ascites samples from patients with spontaneous bacterial peritonitis (SBP) (143)