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This range optimizes the balance between mechanical tension (which preserves muscle) and metabolic stress (which supports fat loss)

Categorical variables were conveyed as frequency with percentage while continuous variables were described as mean and standard deviation (SD) or median with interquartile range (IQR)

About 130 million American adults are eligible for treatment with the drugs under guidelines largely based on a persons weight

For GLP-1R, the -carboxylate spacer formed two hydrogen bonds (with Y145 1.40b and D198 2.68b ), and the 16-carbon palmitic chain terminus dropped down along TM1 with the formation of multiple strong hydrophobic interactions with I146 1.41b , T149 1.44b , V150 1.45b , A153 1.48b and L154 1.49b

Based on this, we synthesized a panel of exendin-4 analogs with single amino acid substitutions close to the N-terminus, which we hypothesized could modulate receptor trafficking and/or signaling (Supplementary Fig