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This is most likely due to the discontinuation of the previous GLP-1 RA therapy and other oral glucose-lowering medications (DPP-4is, glinides and sulfonylureas) at randomisation, combined with the gradual up-titration of IcoSema or escalation of semaglutide from a lower initiating dose than participants were receiving before the trial

There is no solid evidence that GLP-1 meds cause NAION, and the absolute risk if there even is one is so low it barely registers

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The form can be completed online or in the Hims app

Visible particles, cloudiness, or discoloration indicate chemical breakdown and the medication should not be used