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Since ROS-dependent DNA damage is markedly increased in myeloid cells after Bcr-Abl transformation 18 , we hypothesize that blocking dTTP and dCTP supply might exacerbate replication stress and DNA damage in Bcr-Abl-transformed cells, thereby jeopardizing cell survival

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Magnes C, Suppan M, Pieber TR, Moustafa T, Trauner M, Haemmerle G

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Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation