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An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder

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Because of the lethal potential of cyanide toxicity, most organisms have developed effective detoxification mechanisms that classically require sulfur donors, primarily sulfur-containing amino acids, to convert CN into thiocyanate (SCN), a putatively less toxic molecule 9

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