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10.1038/ijo.2015.64 214

Disruption of the BBB is observed in many neurological disorders, including multiple sclerosis, stroke, Alzheimers disease, epilepsy, and traumatic brain injury, and is frequently induced by neuroinflammation [1]

Upon recognition of signals imparted by oxidative and electrophilic molecules, Nrf2 is released from Keap1, escapes proteosomal degradation and translocates to the nucleus to induce genes involved in defense and survival (Kensler et al., 2007)

doi: 10.1128/iai.00053-13 108 OkadaHIkedaTKajitaKMoriIHanamotoTFujiokaKet al

280 showed that ergothioneine attenuated oxidative stress and prevented cognitive deficits in a mouse model of D-galactose-induced dementia