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The different types of disease-associated melanoses listed below are highly correlated with oral/perioral pigmentation and are of prime concern in a differential diagnosis: Addisons disease Peutz-Jeghers syndrome Chronic lichen planus Laugier-Hunziker syndrome Neurofibromatosis McCune-Albright syndrome Kaposi sarcoma The prognosis for oral melanotic macules is excellent, and they are followed and monitored after diagnosis through documentation and photographs/images