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While berberine is generally well-tolerated at recommended doses, several safety considerations warrant attention

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SUSTAIN-6 (cardiovascular outcomes in T2D, Marso et al., NEJM 2016) reported a 26% reduction in MACE versus placebo over 104 weeks, the original cardiovascular signal that established the GLP-1 class's broader metabolic-protection profile beyond glycaemic control

Calcium signaling controls pathogenic Th17 cell-mediated inflammation by regulating mitochondrial function