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Negative Effects and Side Effects: While these medications offer significant benefits, they also come with some gastrointestinal side effects: 1

The Loading Phase Most individuals start at a 2.5 mg dose once per week

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Although its conversion to EPA and DHA is limited, this partial transformation could modulate serotonergic and dopaminergic neurotransmission, which are involved in migraine pathophysiology, as well as attenuating inflammation by inhibiting proinflammatory cytokines and promoting inflammatory resolution, and protecting neuronal membranes from oxidative damage