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Effects of Chenodeoxycholate and a Bile Acid Sequestrant, Colesevelam, on Intestinal Transit and Bowel Function

That binding triggers a rise in cyclic AMP, which then activates a signaling chain that drives melanin production and a range of protective cellular responses: Eumelanin synthesis: MC1R activation stimulates melanocytes to produce eumelanin, the darker, more photoprotective form of melanin

Dosage Starting dose: 2.5 mg once weekly (weeks 14) Weeks 58: 5 mg once weekly Weeks 913: 7.5 mg once weekly Weeks 14+: 10 mg (full dose) once weekly Subcutaneous injection in abdomen, thigh or shoulder area

It also requires planning

On average, patients can expect to lose 1-3 pounds per week, though individual outcomes may vary