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It is typically thought to be well tolerated in animal research

Comment: A commenter recommended CMS collect and disseminate HRSN information since they are better positioned and the HRSN screening falls outside of heart failure and low back pain specialists' clinical scope

The most common types of these anemias are megaloblastic anemia or iron deficiency anemia caused by folate or B12 deficiency

Jastreboff et al., NEJM 2023)

A systematic review in 2025 identified one qualifying clinical study: a retrospective analysis in which 7 of 12 subjects with chronic knee pain reported relief for over six months following intra-articular injection