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In the STEP 1 trial, participants taking Wegovy alongside diet and exercise lost an average of nearly 15% of their body weight over 68 weeks

Furthermore, in another meta-analysis [23], which excluded ELIXA [24] due to fact that lixisenatide is a short-acting GLP-1RA and all participants had acute coronary syndrome, GLP-1RAs were associated with significant reductions in MACE (HR 0.85, 95% CI 0.800.90), cardiovascular death (HR 0.85, 95% CI 0.780.93), stroke (HR 0.81, 95% CI 0.740.90), and myocardial infarction (HR 0.88, 95% CI 0.810.96) (Table 2)

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These findings help clarify how tirzepatide affects complex metabolic pathways in research settings

Side effects and how to manage them Every tirzepatide formulation, whether brand-name or compounded, comes with a predictable set of side effects