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Semaglutide 2.4 mg (Wegovy) has shown robust weight loss in primary obesity trials, with mean weight reductions of 14.9% in the STEP 1 trial published in the New England Journal of Medicine (2021)

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SEMAGLUTIDE REDUCES RESPIRATORY AND CARDIOMYOPATHIC PATHWAY EXPRESSION Using the same thresholding as described above for upregulated proteins, there were 90 downregulated proteins in the semaglutide-treated animals

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