Similar content being viewed by others Introduction After Otto Warburg discovered that cancer cells exhibit significantly elevated glucose consumption and lactate secretion even in the presence of oxygen 1 , studies on cell metabolism have accumulated
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Oxidative stress can occur as a result of increased metabolic rate, increased oxygen tension, compromise of normal cellular antioxidants and many others endogenous and exogenous factors (Figure 1)
(2016), who reported an increase in nitric oxide (NO) synthesis, inducible NO synthase (iNOS) expression, and the levels of tumor necrosis factor- and cytokines in RAW264.7 cells following treatment [75]
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