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The 45S5 in the present study was synthesised using the melt-quench method, resulting in relatively large, dense 530 m particles with an irregular shape

Cell Tissue Res 271 : 169176 Le T and Schimmer BP (2001) The regulation of MAPKs in Y1 mouse adrenocortical tumor cells

Within the classical pyroptosis-regulated pathway, the NLRP3 inflammasome activates the protein hydrolase caspase-1, which subsequently regulates the maturation of protein hydrolysis of GSDMD as well as IL-1 and IL-18, and the N-terminus of the hydrolyzed GSDMD pores in the cell membrane, releasing a large amount of inflammatory factors and cellular contents, which ultimately leads to pyroptosis (159)

This approach has demonstrated unique advantages in addressing complex diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases [8, 9]

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