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For bloating and distension, a large meta-analysis of 82 trials found combination probiotics and Bacillus strains showed benefit, though the authors rated the overall certainty of evidence as low, so this is best framed as "some evidence," not a guarantee

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Tirzepatide activates both GIP and GLP-1 receptors , producing greater average weight loss in head-to-head comparisons with semaglutide

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