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Several medications address specific withdrawal symptoms and can make the process significantly more manageable: Clonidine is a non-opioid blood pressure medication that reduces anxiety, muscle aches, sweating, and agitation during withdrawal

The proposed master mechanism: epithalon binds to specific regions of DNA preferentially methylated cytosine residues and to histone proteins, which influences which genes are accessible for transcription

References: Babu MM, Luscombe NM, Aravind L, Gerstein M, Teichmann SA

(2021) 89:e0073420

"The interaction of copper(II) and glycyl-L-histidyl-L-lysine, a growth-modulating tripeptide from plasma"