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Hence, the upregulation of the thiamine/ThDP-dependent protein transcripts 69 months after gastric bypass (Figures 4B, 5B) maybe a biochemical indicator of thiamine insufficiency in the enterocytes

Oxidative stress serves as a primary activator of the NRF2 pathway, initiating the transcription of antioxidant and detoxification genes that help restore redox balance

& Kaarniranta, K

Promotes cellular repair and protection against oxidative stress

Furthermore, individuals who struggle with being overweight and/or compromised gastrointestinal health require more nutrients to offset underlying malabsorption and intense metabolic needs