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To evaluate in detail how the physical interaction between the NEC and DDX3X impacts viral nuclear egress, we monitored by high-resolution STED confocal microscopy both DDX3X and the viral capsids, as detected with antibodies targeting the main capsid component VP5

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Structurally, DSIP exhibits amphiphilic characteristics, meaning it has both hydrophilic (water-loving) and hydrophobic (water-hating) parts that enables it to interact with both hydrophilic and lipophilic cellular environments

2013;11:e1001571

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