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The Phase 2 trial showed 22.8% average body weight reduction at 48 weeks in the 8mg group

However, to facilitate coordination of Medicare and Medicaid services, the Medicare Improvements for Patients and Providers Act (MIPPA) of 2008--as amended by the Patient Protection and Affordable Care Act--required all DSNPs to have contracts with the states in which they operate (CMS, 2016b)

This happens because the body adapts to the mechanism over time, which may reduce responsiveness

[DOI] [PubMed] [Google Scholar] 98.Alkuraishy H.M., Al-Gareeb A.I., Albuhadilly A.K

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