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Druckers experiments highlighted GLP-1s role in stimulating insulin secretion in response to elevated glucose levels, a finding that suggested GLP-1 could be used to stimulate insulin production in patients with type 2 diabetes, whose natural insulin production is impaired

In addition, given the strong effects of semaglutide on glucose levels, down titrating insulin will prevent rapid decreases in glucose concentrations thereby reducing the risk of acute DRP worsening

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Activated and polarized microglia typically exhibit the pro-inflammatory M1 phenotype and produce pro-inflammatory cytokines, contributing to neuronal dysfunction and reinforcing disease-related behaviors, all of which are related to psychiatric disorders (64, 65)

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