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The prevalence per million individuals in the United States and incidence per million live births are 0.36 and 0.57 for RDEB-sev gen, 0.14 and 0.30 for RDEB-O, and 1.49 and 2.12 for DDEB, respectively.[140] The clinical manifestations demonstrate a continuum of severity that complicates definitive diagnosis, especially early in life
As with other weight-loss medicines, there may be some adverse effects associated with long-term use 11
Cortisol decreased from 19.1 to 16.1 g/dL (normal range 419.5)
Less Common but Important Risks Although uncommon, patients should also be aware of potential serious side effects, including: Severe vomiting with dehydration Gallstones Pancreatitis Significant abdominal pain Persistent severe nausea Allergic reactions Patients should seek medical attention if they develop severe abdominal pain, persistent vomiting, chest pain, dehydration, or concerning symptoms