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Have you lost weight in the past only to gain it back and then some

This article summarizes how human genetics influenced our understanding of the pathophysiological mechanisms leading to obesity and T2D

Biochem Biophys Res Commun 322(1):133146

Unlike oral supplements, which rely on proper digestion and absorption, injectable B12 delivers immediate bioavailability, making it especially beneficial for patients with absorption challenges or low baseline levels

Upon the release of zonulin into the lumen as a result of intestinal exposure to gliadin, zonulin can interact with two receptors, epidermal growth factor receptor (EGFR) and protease-activated receptor 2 (PAR2), which results in increased intestinal permeability (27, 32)