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As a powerful antioxidant, glutathione helps protect cells from oxidative stress, supports detoxification processes, and promotes optimal immune function

Initially, Glutathione Reductase reduces oxidized glutathione (GSSG) to reduced glutathione (GSH) in the presence of NADPH

Besides anti-steatosis, additional benefits of short-term hyperleptinemia may include compensatory cardiac hypertrophy and protection from ischemia/reperfusion injury

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Clinicians on the panel disagreed, saying the requirement would create an administrative burden without added benefit since metformin is nearly universally used as first-line therapy