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These NFTs accumulate inside neurons and interfere with intracellular transport, leading to impaired cell function and neuronal death (Macdonald et al., 2019)

What are the characteristics of the in vitro studies analyzed

However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro (Nelson et al., 2017)

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

2020;1268:12339 Springer