The protective effects of Pycnogenol on DNA, protein or lipid oxidation as well as its effects on blood antioxidant capacity were validated in several RDP studies on cardiovascular health, on cognitive function in older and young people, on menopause and on sports ( , like the reduction of inflammation mediators was shown in RDP trials on joint health as well as on respiratory health ( s favorable impact on blood circulation was demonstrated in multiple ways, like the improvement of endothelial function or microcirculation in clinical RDP trials on cardiovascular health, chronic venous insufficiency, on skin and hair health, eye health and menopause ( on the extracellular matrix, observed in RDP studies ( s positive effects on its largely diversified areas of application
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Disclosure of interest: Lili Laura Bruta: nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.07 - SMALL VESSEL DISEASE P328 - ESOC25-50 CEREBRAL MICROBLEEDS AND THEIR ASSOCIATION WITH INFLAMMATION AND BLOOD BRAIN BARRIER LEAKAGE IN CEREBRAL SMALL VESSEL DISEASE Lupei Cai 1 , Daniel J Tozer 1 , Hugh S Markus 1 1 Stroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom Background and Aims: Cerebral microbleeds (CMBs) are small hypointense lesions visible on paramagnetic-sensitive MR sequences, recognised as a hallmark of small vessel disease (SVD)
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