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In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside wherein the alkyl-glycoside has a critical micelle concentration (CMC) of less than about 1mM in pure water or in aqueous solutions

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The SURMOUNT-4 trial showed that when tirzepatide was continued, people maintained and even augmented weight loss, but when it was withdrawn, significant regain followed

Sridharan, S

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