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[DOI] [PubMed] [Google Scholar] 53.Schmid D., Ricci C., Behrens G., Leitzmann M.F

In adults with obesity/overweight plus at least one comorbidity (no diabetes): 65.3% of patients on 12 mg dropped below a BMI of 30 no longer clinically obese

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Risk Factors Requiring Elevated Screening Personal history of any eating disorder, including sub-threshold presentations, adolescent dieting pathology, or ARFID Family history of restrictive eating, excessive exercise, or diet-culture-driven food restriction High dietary restraint, rigid food rules, or BMI-focused identity Any prior mental health diagnosis doubles two-year eating disorder risk post-initiation Adolescent and young adult patients developmentally most vulnerable Off-label use in patients without metabolic comorbidities the cosmetic use population most likely to include subclinical disordered eating What the Physiology Actually Produces in a Restrictive Mind For a patient with anorexia nervosa in whom the ego-syntonic experience of not being hungry is already rewarding GLP-1-mediated appetite suppression does not feel like a side effect to manage

Clinicians should also consider whether alternative explanations for skin symptoms require investigation, including other medications, supplements, environmental factors, stress, or concurrent medical conditions