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However, we found low heterogeneity between the five trials in all-cause mortality (I 2 = 22%) (Figure 2) and detected no heterogeneity between the two trials reporting heart failure (I 2 = 0%), unstable angina (I 2 = 0%), and myocardial reinfarction (I 2 = 0%) (Figure 3)

Nonteratogenic Effects Fetal/Neonatal Adverse Reactions Use of opioid analgesics for an extended period of time during pregnancy for medical or nonmedical purposes can result in physical dependence in the neonate and neonatal opioid withdrawal syndrome shortly after birth

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Glucagon-like peptide-1 receptor agonist treatment does not reduce abuse-related effects of opioid drugs