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qPCR showed abundant GLP-1R mRNA in islets, lung, and stomach, with similar expression levels observed in both hGLP-1R and mGlp-1r tissues ( Figure 8A )

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In vitro, JKB-121 neutralized or reduced the LPS-induced release of inflammatory cytokines, deactivated hepatic stellate cells, inhibited hepatic stellate cell proliferation, and collagen expression

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