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RNA transcription and subsequent protein synthesis are less affected by folate deficiency, as the mRNA can be recycled and used again (as opposed to DNA synthesis, where a new genomic copy must be created)

10.1016/j.biomaterials.2022.121578 76 KimH.-A.ParkS

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Moreover, mitochondrial damage elevates ROS levels (380), which can in turn damage mtDNA and proteins that may be involved in the electron transport chain (ETC), resulting in lowered ATP production and decreased energy levels (381)

"One of the reasons I was reluctant to use them in the beginning, when I was trying to lose weight after my knee surgery, [is] because I also felt it's cheating, it's the easy way out," she said