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Abstract The bloodbrain barrier (BBB) greatly restricts the entry of biological and engineered therapeutic molecules into the brain

These are secreted by vascular, liver, and immune cells in the presence of fibrin, coagulant factors, and several other stimuli, including cellular stress, histamine, and chemical signals of pain

Finally, this review highlights the value of combined approaches which have been shown to improve clinical efficacy

Conditions like diabetes, heart disease, or obesity increase ED risk