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Similarly, MIA can be modeled in rodents using the toll-like receptor 3 agonist polyriboinosinic-polyribocytidilic acid poly(I:C), which leads to autism-like behavior in offspring (Fujita et al., 2020)

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results showing that oral GLP-1 agonist orforglipron significantly reduced A1C at all doses and induced weight loss at 12 mg and 36 mg versus placebo, with a safety profile consistent with the GLP-1 class