The Role of P53 in Cancer Drug Resistance and Targeted Chemotherapy
Compared with the untreated group, LCN2 treatment markedly increased the proportion of Annexin V-positive osteocytes, indicating enhanced cell death (Fig
doi: 10.3892/mmr.2019.10660 135 DaiRQianYLiuSZouXSunSSunZ
206 CARVEDILOL PLUS NUCS TO PREVENT THE PROGRESSION OF ESOPHAGEAL VARICES IN VIROLOGICAL SUPPRESSED HBV-CIRRHOSIS PATIENTS: A RANDOMISED, OPEN-LABEL TRIAL Bingqiong Wang 1 , Jialing Zhou 1 , Xiaoning Wu 2 , Yameng Sun 2 , Lei Li 3 , Ping Li 4 , Minghui Li 5 , Wei Jiang 6 , Mingyi Xu 7 , Bo Feng 8 , Xiaoyuan Xu 9 , Jilin Cheng 10 , Wen Xie 11 , Tao Han 12 , Xiaozhong Wang 13 , Hai Li 14 , Hongxin Piao 15 , Xinyu Zhao 16 , Shuyan Chen 5 , Tongtong Meng 2 , Qiushuang Guan 1 , Fandong Meng 17 , Yuanyuan Kong 18 , Xiaojuan Ou 2 , Jidong Jia 2 and Hong You 5 , (1)Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China;, (2)Liver Research Center, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center of Digestive Diseases, Beijing, China, (3)Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China, (4)Department of Hepatology, Tianjin Second Peoples Hospital, Tianjin, China, (5)Liver Research Center, Beijing Friendship Hospital, Capital Medical University, (6)Department of Gastroenterology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen 361015, China, (7)Department of Gastroenterology and Hepatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, (8)Peking University People's Hospital, (9)Peking University First Hospital, (10)Department of Gastroenterology, Shanghai Public Health Clinical Center, (11)Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China, (12)Department of Hepatology, Tianjin Third Central Hospital, Tianjin Medical University, (13)The Fourth Affiliated Hospital of Xinjiang Medical University (Xinjiang Hospital of Traditional Chinese Medicine), (14)Department of Gastroenterology, Tianjin Xiqing Hospital, (15)Department of Infectious Diseases, Affiliated Hospital of Yanbian University, (16)Department of Clinical Epidemiology and EBM Unit, National Clinical Research Center for Digestive Diseases, Beijing, China
However, some miRNAs, such as miR-21, also participate in drug resistance by inhibiting the protective autophagy of the cell (220)
