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The Lancet , 386(9991), 256-266

Vanlandewijck et al., 2018) and an intact BBB is vital for maintaining brain homeostasis

Besides lysosomal cholesterol accumulation, mitochondrial cholesterol loading has been shown to sensitize to TNF/Fas-induced steatohepatitis due to mGSH depletion (Mari et al., 2006), and hence it is conceivable that the intracellular cholesterol trafficking to different compartments (i.e., lysosomes and mitochondria) determines APAP hepatotoxicity by different mechanisms including oxidative stress/mitochondrial dysfunction and impaired mitophagy

This could participate, along with other physiological reactions, in the aging process and the onset of age-related diseases

Besides, participants saw significant improvements in cholesterol, blood pressure, blood sugar levels, and triglyceride reduction