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Physiological Functions Beyond its original sleep-promoting properties, DSIP exhibits a remarkably broad range of biological activities: Neuromodulatory Effects : DSIP influences various neurotransmitter systems, including GABA, serotonin, and dopamine pathways

2025 Apr 29:50:525-539

GLP-1RA and GIP/GLP-1RA, although structurally similar to endogenous incretins, are resistant to inactivation by DPP-4, which prolongs their effects (Figure 1)

The concept of this molecular mimicry has been mentioned in studies, but detailed information in this regard is not yet available

NICE recommends GLP-1 receptor agonists for type 2 diabetes when metformin and other oral medications fail to achieve adequate glycaemic control, particularly with BMI 35 kg/m or weight-related comorbidities