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Kidney Protection and Brain Health A trial found semaglutide reduced kidney events by 24% in people with type 2 diabetes and chronic kidney disease using a lower dose, not the maximum. GLP-1s also strengthen the blood-brain barrier and enhance neuron survival, with early data hinting at benefits for cognitive decline and Alzheimer's disease. Systemic Anti-Inflammatory Effects GLP-1s reduce systemic inflammation throughout the body. This benefit doesn't get talked about much, though inflammation drives almost every chronic disease

Reviewing the FDA's current public guidance before making treatment decisions is a practical step worth taking

Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue

doi: 10.1186/s12933-022-01512-w 22 Fonseca-CorreaJICorrea-RotterR

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