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It represents the most abundant non-protein thiol in mammalian cells, present at millimolar concentrations (110 mM) in the cytosol 1

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The GAIN Act seeks to streamline the approval process for these repurposed drugs so that they can be given market clearance

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The presence of human hepsin in hepsin / mouse serum and liver lysate was confirmed and quantified via enzyme-linked immunosorbent assay (ELISA) and western blot on Day 14 after administering the same dose of AAV-hHPN WT , AAV-hHPN RS or AAV-EGFP (Fig