Facilitating the translation of nanomedicines to a clinical product: challenges and opportunities
doi:10.1210/jc.2017-01155
While safe at therapeutic doses of up to 4 grams per day for adults, acetaminophen overdoses, either accidental or intentional, are the leading cause of acute liver failure in the United States, accounting for some 56,000 emergency room visits, 2,600 hospitalizations and nearly 500 deaths annually[2, 3]
The intranasal administration in rats typically requires anesthesia, although devices are being developed to circumvent this limitation
Using a nasal spray format could have certain advantages in terms of: Convenience Dosing Administration Quicker delivery to the target site Due to increased interest in administering BPC-157 and TB-500 together, our research team has created this informative guide to discuss the potential benefits and drawbacks of using this peptide blend as a spray