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Pre-specified outcomes The primary outcome was defined as the annual rate of acute healthcare utilization (number of events per year of follow-up): calculated as the sum of urgent care visits, Emergency Department visits, and hospitalizations divided by the duration of follow-up

In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes

The available comparative evidence is fragmented: it includes observational head-to-head studies and comparisons with active comparators, primarily DPP-4 inhibitors (DPP-4i) [7,8,9] as well as specific contexts such as the orthopedic perioperative setting [10]