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A meta-analysis by Faraone and Buitelaar (2010) pooling data from multiple randomized controlled trials found that amphetamine-based medications had a modestly larger mean effect size (SMD 0.99) for ADHD symptom reduction compared to methylphenidate-based medications (SMD 0.78) [6]

And honestly, this distinction is one of the most important concepts to grasp if you're navigating treatment for type 2 diabetes or exploring options for significant weight loss in 2026

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In general a Cohen's d effect size between 0.2 and 0.4 is small, between 0.5 and 0.7 is medium and 0.8 or above is large

Understanding Dosage and Titration for GLP-1 Medications If youre considering or have recently started a GLP-1 medication, you might be wondering what to expect in terms of dosage and titration