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However, the mechanisms in humans are still being studied, and larger randomized trials are needed to figure out how generalizable these effects are

The bottom line The European Medicines Agency, having looked at all of this imperfect data, recommended last month that the information leaflet that comes with semaglutide (Ozempic, Wegovy and, in its pill form, Rybelsus) now include NAION as a side effect, qualifying its frequency as very rare. The World Health Organization agreed with this assessment