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Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism editorial team

We will highlight why a personalized, medically supervised approach is not just beneficial but essential when considering such potent medications

Proc Natl Acad Sci USA 105, 50345039 (2008)

(2021) 70:e12730

Specifically, IRE enhances systemic antitumor T-cell activation while downregulating immunosuppressive mechanisms in localized disease, promoting tumor antigen-specific expansion of tissue-resident memory CD8 + T cells (TRM) for durable immune surveillance ( In vitro and magnetic resonance imaging (MRI) assessments further validate IREs ability to achieve sustained tumor regression ( 3.4 Melanoma PEFs represent a highly suitable therapeutic approach for melanoma, primarily because these tumors are typically located in superficial layers, allowing for direct percutaneous minimally invasive intervention that yields clinically significant outcomes