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In healthy aging, attenuated circadian amplitude and phase shifts may represent adaptive recalibration of the circadian system, optimizing energy expenditure, sleepwake timing, and metabolic processes under age-related physiological constraints

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Plain sterile water does not contain preservatives, meaning bacteria can grow quickly once the vial is punctured for the first time

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However, it is possible that the BHBA-induced changes of H2AK119ub, in turn, can further influence the Ca 2+ concentration by affecting the expression of calcium channels such as Cav1.2