When Selectivity Matters Most: The selective action of AOD-9604 is particularly valuable for individuals with insulin resistance, pre-diabetes, or type 2 diabetes who cannot tolerate glucose elevation, those with personal or family history of cancer who wish to avoid IGF-1 elevation, people seeking pure fat loss without muscle gain or other body composition changes, athletes who need fat loss without anabolic effects or hormonal changes that might affect testing, individuals on complex medication regimens where growth hormones effects would require dose adjustments, and those who prefer targeted interventions over systemic hormonal therapy
Hayashi, T
Two new studies find no effect of GLP-1 receptor agonists on acute pancreatitis risk, but increased risk of bile duct and gallbladder disease
The pharmaceutical industry is developing newer and potentially cheaper or more effective molecules that target GLP-1 and associated pathways (for example, the so-called dual- and triple-agonists tirzepatide, retatutride and orfoglipon) 257,258
The liver filters out most of the B12 but provides a constant stream in the blood to the rest of the body