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Not sure what scientific backing they have for most of the claims made on their 'learn more' page - most of which looks biased at best - and really not sure where the claim that you will lose the effect of the shot more quickly if you drink more water comes from - never come across any studies that would imply that was true - it also claims that B12 isn't stored in the body and because it is water soluble which is definitely a load of twaddle