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10.1016/j.amepre.2011.09.013 28 GutsaevaD

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This is the sharpest single difference in the comparison, and it colors every downstream statement about dosing and safety

Differences in continuous variables among diagnostic groups were analyzed using the KruskalWallis test with multiple comparisons adjusted with Bonferroni

(2012) demonstrated: Statistically significant reductions in visceral adipose tissue of approximately 1518% over 26 weeks compared to placebo Meaningful increases in IGF-1 levels Improvements in triglyceride profiles in some patient subgroups Effects were partially reversed upon discontinuation, suggesting that sustained benefit requires ongoing therapy The consistency of the VAT reduction finding across multiple trials is what anchors tesamorelin's clinical utility