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Studies have demonstrated the presence of mitochondria-induced myopathies caused by reduced respiratory enzyme activity, calcium leakage, and oxidative stress in patients treated with statins in addition to rhabdomyolysis reported in 1 in 10,000 patients (Stoker et al., 2019

Functional validation using receptor-deficient models confirms that 3-adrenergic signaling is required for these effects, as disruption of this pathway attenuates peptide-induced lipolysis

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Phytoene and phytofluene may also help with glutathione production [5]