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Certain nutrient deficiencies have been associated with early graying

Eriksson 1999)

Nevertheless, this reductionist approach enabled us to isolate the direct effects of Rot on cortical neurons and to demonstrate that generalized mitochondrial disruption alone is sufficient to impair key neurodevelopmental processes

This reduction was prevented by MG132 (proteasome inhibitor) but not Lys05 (lysosome inhibitor), indicating that SLC7A11 protein is degraded via the ubiquitin-proteasome pathway rather than the lysosomal pathway [47]